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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often focused on the practical aspects of study design, including the recruitment and consent process in adherence, as well as the use of commonly available equipment.
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A practical trial that employs a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for pragmatic trials to be reliable and to reduce bias in the results is also essential. A high degree of heterogeneity, however, can cause problems with the trial design.
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Legality
Pragmatic Play has earned a reputation for providing high-quality games and a superior user experience. The software is available on mobile devices and in multiple languages. It has been recognized as one of the top gaming platforms in the casino industry despite its relatively young age. Wolves is one of the most recent releases that is a 5-reel slot machine with a hefty RTP and impressive graphics. Its other notable titles are Wolf Gold and Chilli Heat.
The purpose of pragmatic trials is to simulate real-life situations and achieve maximum credibility externally. They are usually commissioned by practitioners and policy makers to guide their decision-making. They are also a good method to determine the causal relationship between the intervention and its effects. However, they should not, be used to replace the need for explanation studies.
The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm a physiological or clinical hypothesis, and pragmatic trials that inform policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic study, including recruitment, design, delivery of the intervention, and follow-up.
There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) produced 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming more sensitive to the issue of pragmatism. It is important to keep in mind that the majority of these trials were conducted in primary care settings.